The development of dual-agonist compounds that simultaneously target both receptors opened a new chapter in incretin pharmacology research
After food intake, the active form of GLP-1 is released into the circulation and activates specific G-protein coupled receptors
During semaglutide treatment, regular follow-up appointments should include blood pressure and heart rate monitoring at each visit, with reporting of any new symptoms such as dizziness, chest discomfort, or unusual palpitations
A 0.5% topical solution worked better than lower concentrations
Additionally, the FDA continued its regulatory action against the sale/distribution of unapproved opioid products
The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients